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[Genotype study on hepatitis C among entry foreigners in China]
Lübo Tian1, Xiaoxiao Chen1, Liming He1
1Sichuan Entry-exit Inspection and Quarantine Bureau International Travel Healthcare Center, Chengdu 610041, China.
Zhonghua Yi Xue Za Zhi
|June 18, 2015
Summary
Hepatitis C genotype 1b is most common in immigrants. New genotype 4 strains detected in immigrants may have originated from Egypt and Europe, suggesting immigrants as a potential source of new hepatitis C virus (HCV) genotypes in China.
Area of Science:
- Virology
- Epidemiology
- Genetics
Background:
- Hepatitis C virus (HCV) infection remains a significant global health concern.
- Understanding HCV genotype distribution is crucial for effective treatment and prevention strategies.
- Immigration can introduce and alter the epidemiological landscape of infectious diseases.
Purpose of the Study:
- To determine the prevalence of HCV genotypes and subtypes among immigrants.
- To identify potential novel HCV genotypes and transmission pathways.
- To trace the origins of detected HCV strains.
Main Methods:
- Collection of 235 Anti-HCV positive samples from immigrants between 2009 and 2013.
- Amplification of the HCV Core gene using specific PCR primers.
- Sequencing of PCR products and phylogenetic analysis to identify genotypes and subtypes.
Main Results:
- HCV-RNA was detected in 54.9% of samples (129/235).
- Six HCV genotypes were identified, with Genotype 1 (G1) being the most prevalent (62.6%), particularly subtype 1b (47%).
- HCV genotype 4 strains showed affinity to those from Egypt/Europe, while genotype 6 strains were similar to Chinese strains.
Conclusions:
- HCV genotype 1b is the dominant genotype among the studied immigrant population.
- HCV genotype 4 detected in immigrants may represent a newly introduced genotype in China.
- Immigrants could be a potential source for the introduction of new HCV genotypes into China.
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