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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
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Factors Affecting Medium-Term Outcomes After Crural Angioplasty in Critically Ischemic Legs
K Mathur1, M K Ayyappan1, J Hodson2
1Department of Vascular Surgery, Queen Elizabeth Hospital, Birmingham, United Kingdom.
Vascular and Endovascular Surgery
|June 18, 2015
Summary
Crural angioplasty effectively saves limbs, but outcomes depend on patient factors. Diabetes, kidney disease, and severe peripheral artery disease negatively impact patency and limb salvage rates.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Endovascular Therapy
Background:
- Crural angioplasty is a key intervention for critical limb ischemia.
- Understanding factors influencing its long-term success is crucial for patient management.
Purpose of the Study:
- To identify factors affecting the patency and medium-term outcomes of crural angioplasty.
- To evaluate the effectiveness of crural angioplasty in limb salvage.
Main Methods:
- A prospective database review of 527 crural angioplasties performed between March 2003 and September 2010.
- Analysis of primary patency, amputation-free survival, and limb salvage rates.
- Assessment of patient comorbidities and disease severity (Rutherford grade).
Main Results:
- Primary patency rates at 1, 6, 12, and 36 months were 65.5%, 57.8%, 48.5%, and 32.9%, respectively.
- Amputation-free survival was 75.2% at 1 year and 59.0% at 3 years; 3-year limb salvage was 92.7%.
- Diabetes, renal disease, coronary disease, and higher Rutherford grades (5-6) were associated with adverse outcomes.
Conclusions:
- Crural angioplasty is an effective treatment for limb salvage in patients with peripheral artery disease.
- Patient comorbidities, particularly diabetes and renal disease, significantly impact angioplasty outcomes.
- Optimizing treatment strategies based on patient risk factors may improve crural angioplasty results.
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