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Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
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Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

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Upregulated GABA Inhibitory Function in ADHD Children with Child Behavior Checklist-Dysregulation Profile:

Shinichiro Nagamitsu1, Yushiro Yamashita1, Hitoshi Tanigawa2

  • 1Department of Pediatrics and Child Health, Kurume University School of Medicine , Fukuoka , Japan.

Frontiers in Psychiatry
|June 18, 2015
PubMed

Insights

GABA inhibitory neurons may be crucial in attention deficit/hyperactivity disorder (ADHD) with dysregulation. Brain imaging revealed differences in GABAergic activity in children with ADHD and a significant Child Behavior Checklist-Dysregulation Profile (CBCL-DP).

Area of Science:

  • Neuroscience
  • Child Psychiatry
  • Neuroimaging

Background:

  • The Child Behavior Checklist-Dysregulation Profile (CBCL-DP) signifies elevated scores in attention problems, aggression, and anxiety/depression.
  • Attention deficit/hyperactivity disorder (ADHD) is often associated with behavioral dysregulation.

Purpose of the Study:

  • To explore the role of GABA inhibitory neurons in children diagnosed with ADHD and exhibiting dysregulation.
  • To correlate brain imaging findings with behavioral assessments in pediatric ADHD.

Main Methods:

  • Brain single photon emission computed tomography (SPECT) was conducted on 35 children with ADHD.
  • 123I-iomazenil, a benzodiazepine receptor ligand, was used to assess GABAergic activity.
  • Iomazenil binding was analyzed in relation to the CBCL-DP threshold and its subscales, controlling for age, sex, and maltreatment history.

Main Results:

  • Children with ADHD and a significant CBCL-DP showed higher iomazenil binding in the posterior cingulate cortex (PCC).
  • The Anxiety/Depression subscale of the CBCL significantly correlated with increased iomazenil binding in the left superior frontal, middle frontal, temporal regions, and PCC.

Conclusions:

  • GABAergic inhibitory neurons appear to play a significant role in the neurobiology of the CBCL-DP in children with ADHD.
  • These findings highlight potential neurobiological underpinnings of behavioral dysregulation in pediatric ADHD.

Keywords:
ADHDCBCL-dysregulation profileGABAiomazenil

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