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Asymmetrical Flow Field-Flow Fractionation for Sizing of Gold Nanoparticles in Suspension

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Sizing Individual Au Nanoparticles in Solution with Sub-Nanometer Resolution.

Sean R German^1,2, Timothy S Hurd², Henry S White¹

¹†Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.

|June 18, 2015

Summary

This summary is machine-generated.

This study introduces a new method for nanoparticle characterization using repeated translocations through a nanopore. This technique significantly improves measurement accuracy for nanoparticle size and surface charge, overcoming limitations of traditional resistive-pulse sensing.

Keywords:

Coulter method nanoparticles nanopore particle sizing resistive-pulse analysis

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Area of Science:

Nanotechnology
Materials Science
Analytical Chemistry

Background:

Resistive-pulse sensing is a key technique for nanoparticle characterization.
Stochastic translocation of particles causes inherent variability in measurements.
Existing methods struggle with precise determination of size, charge, and shape.

Purpose of the Study:

To develop an improved method for accurate nanoparticle characterization.
To reduce measurement uncertainty in resistive-pulse sensing.
To enable precise differentiation of nanoparticles based on size and surface charge.

Main Methods:

Developed a method for repeated, pressure-driven translocation of individual nanoparticles across a nanopore.
Utilized automated instrumentation for consistent particle movement.
Analyzed resistive pulses generated during repeated translocations.

Main Results:

Achieved ~0.3 nm resolution in measuring the size of gold nanoparticles.
Successfully distinguished gold nanoparticles differing by ~1 nm in radius.
Demonstrated differentiation of particles based on surface charge density.

Conclusions:

Repeated translocation significantly reduces uncertainty in nanoparticle size measurements.
The method enhances the capability of resistive-pulse sensing for detailed nanoparticle analysis.
Provides new insights into factors influencing measured nanoparticle size distributions.