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Updated: Apr 9, 2026
Preparation and Reactivity of a Triphosphenium Bromide Salt: A Convenient and Stable Source of PhosphorusI
Published on: November 22, 2016
Synthetic applications of hypophosphite derivatives in reduction
Carole Guyon1, Estelle Métay, Florence Popowycz
1Equipe Catalyse Synthèse Environnement, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, UMR-CNRS 5246, Université de Lyon, Université Claude Bernard-Lyon 1, Bâtiment Curien, 43 boulevard du 11 Novembre 1918, F-69622 Villeurbanne Cedex, France. estelle.metay@univ-lyon1.fr.
Abstract:
The development of new tools for the reduction of organic functions to reach high chemo- and stereo-selectivity is an important research domain. Although, aluminum and boron hydrides are commonly used, they suffer from environmentally and safety issues. In particular, at industrial scale, the search for more specific and efficient reagents with a lower ecological impact remains one of the main objectives of organic chemists. This review captures highlights from literature concerning phosphonic and phosphinic acid derivatives as reducing agents and evaluates their potential as alternatives, in particular to boron and aluminum hydrides.
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