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Synthesis and properties of oligodeoxyribonucleotides containing N6-methoxyadenine
1Faculty of Pharmaceutical Science, Hokkaido University, Sapporo, Japan.
Nucleic Acids Symposium Series
|January 1, 1989
Abstract:
Oligodeoxyribonuclotides containing N6-methoxyadenine (mo6A), a promutagenic base, were synthesized. The Tm values and thermodynamic parameters for double strand formation of d(CCTGGTAmo6ACAGGTCC) have been measured. The order of the base-pair stability was A-T greater than mo6A-C approximately equal to mo6A-T greater than A-C.