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Synthesis of dinucleoside phosphorodithioates from nucleoside phosphonodithioates
1Department of Chemistry, King's College London, UK.
Nucleic Acids Symposium Series
|January 1, 1989
Abstract:
The conversion, in good yield, of 5'-O-(9-phenylxanthen-9-yl) thymidine (1) into the triethylammonium salt of its 3'-phosphonodithioate (2a) is described. The latter compound (2a) is converted into a dinucleoside phosphonothioate (4a), and thence into a corresponding dinucleoside phosphorodithioate (6a) and phosphorothioate (6;X = 0).