Related Experiment Video
Updated: Apr 9, 2026

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
Host Range Restriction of Epstein-Barr Virus and Related Lymphocryptoviruses
1Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, and Department of Molecular Biology & Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Abstract:
Epstein-Barr-related herpesviruses, or lymphocryptoviruses (LCV), naturally infect humans and nonhuman primates (NHP), but their host range is not well characterized. Using LCV and B cells from multiple species of Hominidae and Cercopithecidae, we show that LCV can immortalize B cells from some nonnative species but that growth transformation is restricted to B cells from their own family of hominoids or Old World NHP, suggesting a high degree of LCV adaptation to their natural primate host.

