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An Isoflavone from Leiophyllum buxifolium and Its Antiproliferative Effect
1†Program in Pharmacognosy, Department of Chemistry and Biochemistry, and ‡Department of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania 19104, United States.
Abstract:
A new C-methylisoflavone, isosideroxylin (1), and a known C-methylflavone, sideroxylin (2), were isolated from the EtOAc extract of the leaves of Leiophyllum buxifolium. The two compounds were evaluated with the sulforhodamine B assay for their antiproliferative effects against ER(-) MDA-MB-231 and ER(+) MCF-7 breast cancer cell lines and the NIH3T3 mouse fibroblast cell line. Isosideroxylin (1) displayed a selective antiproliferative effect against MDA-MB-231 cells.

