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Sepsis-Associated Outcomes in Critically Ill Patients with Malignancies
Viviane B L Torres1, Luciano C P Azevedo2,3, Ulysses V A Silva4
11 Postgraduate Program in Internal Medicine, School of Medicine, Universidade Federal do Rio de Janeiro.
Annals of the American Thoracic Society
|June 19, 2015
Summary
Sepsis in cancer patients leads to high mortality. Factors like organ dysfunction, hematological malignancies, and polymicrobial infections significantly increase the risk of death in these critically ill individuals.
Area of Science:
- Critical Care Medicine
- Oncology
- Infectious Diseases
Background:
- Sepsis is a leading cause of death in critically ill cancer patients.
- Understanding clinical outcomes and risk factors is crucial for targeted interventions and improved ICU care.
Purpose of the Study:
- To characterize clinical features of cancer patients with sepsis.
- To identify independent risk factors for hospital mortality in this population.
Main Methods:
- Subgroup analysis of a multicenter prospective cohort study.
- Inclusion of adult cancer patients with severe sepsis or septic shock from 28 Brazilian ICUs.
- Logistic regression analysis to determine factors associated with hospital mortality.
Main Results:
- 268 cancer patients with severe sepsis or septic shock were analyzed.
- Hospital mortality rate was 56%, with ICU mortality at 42%.
- Independent risk factors for mortality included increased organ dysfunction, hematological malignancies, poor performance status, and polymicrobial infections.
Conclusions:
- Sepsis remains a significant cause of mortality in cancer patients.
- Prognosis is poor, influenced by malignancy type, sepsis severity, and infection characteristics.
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