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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

Non-LTR Retrotransposons

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...

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Related Experiment Video

Updated: Apr 9, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Long noncoding RNAs and neuroblastoma.

Gaurav Kumar Pandey¹, Chandrasekhar Kanduri¹

¹Department of Medical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

|June 19, 2015

Summary

This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are emerging as key players in neuroblastoma, a childhood cancer. Understanding their roles could improve prognosis and treatment for high-risk neuroblastoma patients.

Keywords:

MYCN NBAT1 neuroblastoma neuronal differentiation noncoding RNA

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Last Updated: Apr 9, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Neuroblastoma affects infants, with poor survival rates for high-risk patients despite aggressive treatment.
Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in various cancers.
The specific functions of lncRNAs in neuroblastoma are still under investigation.

Purpose of the Study:

To review the current understanding of lncRNAs in neuroblastoma.
To discuss the mechanistic roles of lncRNAs in neuroblastoma development.
To explore the link between lncRNA expression and neuroblastoma cell differentiation.

Main Methods:

Literature review of studies on lncRNAs and neuroblastoma.
Analysis of known mechanistic roles of lncRNAs in cancer pathogenesis.
Examination of the relationship between lncRNA expression and neuroblastoma cell differentiation capacity.

Main Results:

lncRNAs play significant roles in neuroblastoma pathogenesis.
Specific lncRNAs are associated with the differentiation capacity of neuroblastoma cells.
lncRNAs mapping to the 6p22 hotspot show potential as biomarkers.

Conclusions:

lncRNAs offer a novel perspective on neuroblastoma prognosis and treatment.
Further research into lncRNAs could lead to improved therapeutic strategies for high-risk neuroblastoma.
lncRNAs may serve as valuable biomarkers for neuroblastoma patient outcomes.