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Related Concept Videos

Histology of the Small Intestine01:27

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The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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The large intestine, a vital component of the gastrointestinal tract, is structured with four main layers: the mucosa, submucosa, muscularis, and serosa. Each layer performs a distinct role in facilitating the smooth functioning of the large intestine.
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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Related Experiment Video

Updated: Apr 9, 2026

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
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[Evolution of ideas on microscopic colitis].

I V Maev1, Yu A Kucheryavyi1, D N Andreev1

  • 1A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia.

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Summary
This summary is machine-generated.

Microscopic colitis (MC) is an inflammatory bowel disease causing chronic watery diarrhea. Budesonide is the only proven treatment for inducing and maintaining remission in MC patients.

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Area of Science:

  • Gastroenterology
  • Inflammatory Bowel Disease (IBD)
  • Colitis Research

Context:

  • Microscopic colitis (MC) is an under-recognized inflammatory bowel disease.
  • Characterized by chronic watery diarrhea without macroscopic colonic abnormalities.
  • Prevalence is approximately 100 per 100,000, comparable to other IBDs.

Purpose:

  • To review current understanding of microscopic colitis definition, etiology, pathogenesis, diagnosis, and treatment.
  • To highlight the distinct histological criteria for collagenous colitis (CC) and lymphocytic colitis (LC).
  • To summarize the efficacy of budesonide in MC management.

Summary:

  • MC presents with chronic watery diarrhea, with specific histological findings differentiating CC and LC.
  • Etiology and pathogenesis remain largely unknown.
  • Topical budesonide is the sole evidence-based therapy for inducing and maintaining remission.

Impact:

  • Provides a comprehensive overview of microscopic colitis for clinicians and researchers.
  • Emphasizes the diagnostic criteria and current therapeutic strategies.
  • Highlights the need for further research into MC etiology and pathogenesis.