LIPID PROFILE AND CYTOKINES INTERACTIONS DURING SUCCESSFUL AGING

Area of Science:

• Immunology and Gerontology
• Cardiovascular Health

Background:

• Aging compromises homeostasis, increasing susceptibility to diseases.
• Chronic low-grade inflammation and immunosenescence are hallmarks of aging.
• Age-related cytokine level alterations are inconsistently reported.

Purpose of the Study:

• To investigate age-related changes in pro- and anti-inflammatory cytokines and lipoproteins.
• To explore the interrelationships between these factors in healthy individuals.
• To identify potential biomarkers for age-associated health risks.

Main Methods:

• Analysis of 220 healthy volunteers, excluding those with health issues.
• Measurement of triglycerides (TG), LDL, HDL, and cytokines (IL-6, IL-4, IL-10, IL-17, IFN, TNF).
• Statistical analysis using SPSS to assess gender and age-related variations and correlations.

Main Results:

• Cytokine levels did not vary by gender; LDL levels differed significantly.
• Age predicted changes in LDL, IL-17, and IL-10, with LDL and IL-17 increasing and IL-10 decreasing.
• LDL correlated with TNF-alfa and IL-10; TG correlated with IL-10, independent of age.

Conclusions:

• Lipoprotein levels (LDL, TG) and specific cytokines (TNF, IL-10, IL-17) show age-dependent alterations.
• These factors are interconnected and may serve as prognostic markers for cardiovascular disease development.
• Findings highlight the link between aging, inflammation, and cardiovascular risk.