ASSOCIATION OF IL-10 AND RESISTIN IN APPARENTLY HEALTHY ELDERLY POPULATION

There is a growing body of evidence suggesting that the elderly population is characterized by chronic low-grade inflammation ("inflammaging"). Age associated inflammation can be caused by a decrease in the level of IL-10, one of the anti-inflammatory cytokines during aging. The binding of IL-10 to adipose tissue is very important. In rats, IL-10 has also been shown to effect on adipocytes and may be considered as a therapeutic agent for the prevention of age-related glucose metabolism. Adipocytes, which increase in overweight individuals, synthesize various adipokines that directly or indirectly affect the number and balance of cytokines, which in turn further aggravates the inflammatory status. The goal of our research was to study age-related changes of plasma levels of IL-10 and pleiotropic resistin and their potential association. The study was carried out on 150 apparently healthy volunteers (from 20 to 90 years old). Anthropometric data were collected for each individual using a special questionnaire. Individuals who had pathologies affecting the immune system were not included in the study. Plasma levels of IL-10 and resistin were measured using commercial ELISA set (Thermofisher scientific, USA) according to the protocol. The results revealed that there is a statistically significant difference in every parameter between female and male except of resistin. IL-10 levels are elevated in postmenopausal women (P< 0.05). While in men il-10 correlated reliably with height and diastolic blood pressure. The results indicate a direct statistically significant correlation between IL-10 and resistin only in postmenopausal women. To our knowledge, this is the first study to demonstrate that the IL-10 is correlated with the resistin levels in postmenopausal women.