Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

21.0K
Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
21.0K
Radical Reactivity: Overview01:11

Radical Reactivity: Overview

3.0K
Radicals, the highly reactive species, gain stability by undergoing three different reactions. The first reaction involves a radical-radical coupling, in which a radical combines with another radical, forming a spin‐paired molecule. The second reaction is between a radical and a spin‐paired molecule, generating a new radical and a new spin‐paired molecule. The third reaction is radical decomposition in a unimolecular reaction, forming a new radical and a spin‐paired...
3.0K
Reactivity of Enols01:18

Reactivity of Enols

4.5K
Enols are a class of compounds where a hydroxyl group is attached to a carbon–carbon double bond, which implies that it is a vinyl alcohol. A carbonyl compound with an α hydrogen undergoes keto–enol tautomerism and remains in equilibrium with its tautomer, the enol form. Usually, the keto tautomer is present in a higher concentration than the enol tautomer due to the higher bond energy of C=O compared to C=C. Moreover, the direction of the keto–enol equilibrium is...
4.5K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

17.5K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
17.5K
Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

113.7K
Overview
113.7K
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

12.5K
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
12.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Reactome Knowledgebase 2026.

Nucleic acids research·2025
Same author

Advancing curation of viral life cycles, host interactions, and therapeutics in Reactome.

Journal of virology·2025
Same author

Pathway-based, reaction-specific annotation of disease variants for elucidation of molecular phenotypes.

Database : the journal of biological databases and curation·2024
Same author

The Reactome Pathway Knowledgebase 2024.

Nucleic acids research·2023
Same author

Pathway-based, reaction-specific annotation of disease variants for elucidation of molecular phenotypes.

bioRxiv : the preprint server for biology·2023
Same author

Using the Reactome Database.

Current protocols·2023

Related Experiment Video

Updated: Apr 9, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.9K

Installing a Local Copy of the Reactome Web Site and Knowledgebase.

Sheldon J McKay1, Joel Weiser1

  • 1Ontario Institute for Cancer Research, Toronto, Ontario, Canada.

Current Protocols in Bioinformatics
|June 20, 2015
PubMed
Summary

Reactome provides an open-source, peer-reviewed knowledgebase of biological pathways. This curated resource is freely available for download and local installation, enabling flexible data analysis and custom additions.

More Related Videos

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

2.3K
A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.7K

Related Experiment Videos

Last Updated: Apr 9, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.9K
A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

2.3K
A Web Tool for Generating High Quality Machine-readable Biological Pathways
08:01

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

18.7K

Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Systems Biology

Background:

  • Biological pathways are fundamental to cellular functions.
  • Existing pathway databases may lack comprehensive curation or accessibility.
  • The Reactome project addresses the need for a robust, curated pathway knowledgebase.

Purpose of the Study:

  • To describe the Reactome project and its knowledgebase of biological pathways.
  • To highlight the open-source nature and accessibility of Reactome resources.
  • To emphasize the collaborative and expert-driven curation process.

Main Methods:

  • Information is gathered from domain experts in the field.
  • Data undergoes peer review and editorial refinement by Reactome staff.
  • The Reactome software is open-source, built upon existing free software.

Main Results:

  • A comprehensive, curated knowledgebase of biological pathways is maintained and published.
  • The Reactome website (http://www.reactome.org) serves as the primary access point.
  • Reactome data and software are freely downloadable for local installation.

Conclusions:

  • Reactome offers a valuable, freely accessible resource for biological pathway research.
  • The open-source model and local installation options facilitate flexible data interrogation.
  • Users can contribute their own information, enhancing the knowledgebase collaboratively.