Related Experiment Video
Updated: Apr 9, 2026
Investigating Intestinal Barrier Breakdown in Living Organoids
Published on: March 26, 2020
Is intestinal inflammation linking dysbiosis to gut barrier dysfunction during liver disease?
Katharina Brandl1, Bernd Schnabl
1Skaggs School of Pharmacy, University of California San Diego, 9500 Gilman Drive La Jolla, California.
Abstract:
Changes in the intestinal microbiota composition contribute to the pathogenesis of many disorders including gastrointestinal and liver diseases. Recent studies have broadened our understanding of the "gut-liver" axis. Dietary changes, other environmental and genetic factors can lead to alterations in the microbiota. Dysbiosis can further disrupt the integrity of the intestinal barrier leading to pathological bacterial translocation and the initiation of an inflammatory response in the liver. In this article, the authors dissect the different steps involved in disease pathogenesis to further refine approaches for the medical management of liver diseases. The authors will specifically discuss the role of dysbiosis in inducing intestinal inflammation and increasing intestinal permeability.
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