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SERS investigation of ciprofloxacin drug molecules on TiO2 nanoparticles
Libin Yang1, Xiaoyu Qin, Xin Jiang
1Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun 130012, People's Republic of China. yingjiu@jlu.edu.cn.
Abstract:
In this paper, TiO2 nanoparticles (NPs) with different crystallinity served as SERS-active substrates for SERS detection of ciprofloxacin (CIP) drug molecules for the first time. CIP is close to the surface of the TiO2 substrate through the carboxyl group. The mutual SERS enhancement behaviors between CIP molecules and TiO2 NPs were discovered, which are attributed to the contribution of the TiO2-to-molecule charge-transfer mechanism. The crystallinity of TiO2 NPs, the pH value of adsorption solution and the adsorption time have significant influences on the interaction and the SERS behavior between CIP and TiO2. When the calcination temperature of TiO2 NPs is 450 °C, the pH value of adsorption solution is 6 and the adsorption time is 9 h, the CIP molecules on TiO2 NPs exhibit the largest SERS enhancement.
