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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Responsive foams for nanoparticle delivery.

Christina Tang1, Edward Xiao2, Patrick J Sinko3

  • 1Department of Chemical Engineering, Princeton University, Princeton, NJ 08544, United States; Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23284, United States.

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We created responsive foams for nanoparticle delivery that break down with temperature or moisture changes. This versatile system offers a simple method for pharmaceutical and personal care applications.

Keywords:
FoamsNanoparticleQuick-breakSurfactant

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Area of Science:

  • Materials Science
  • Biotechnology
  • Chemical Engineering

Background:

  • Nanoparticle delivery systems require stable yet responsive formulations.
  • Existing methods for controlled release can be complex or lack versatility.

Purpose of the Study:

  • To develop novel responsive foam systems for efficient nanoparticle delivery.
  • To engineer foams that respond to specific environmental triggers like temperature or moisture.

Main Methods:

  • Developed temperature-responsive foams utilizing long-chain alcohol phase transitions and nitrous oxide propellant.
  • Created moisture-responsive foams using soap pump dispensers with biocompatible detergents.
  • Incorporated polyacrylic acid (PAA)-based, polyethylene glycol (PEG)-based, and PMMA latex nanoparticles into Tween 20 foams.

Main Results:

  • Foams demonstrated stability at room temperature and responsiveness to temperature or moisture.
  • Nanoparticle size remained unaffected by foam formulation or breakdown.
  • The developed foams are easy to fabricate and engineer for specific release profiles.

Conclusions:

  • Responsive foams offer a versatile and simple platform for nanoparticle delivery.
  • Potential applications span the pharmaceutical and personal care industries.
  • This approach facilitates controlled release of various nanoparticle types.