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Repeated doses of albendazole against strongyloidiasis in Thai children

P Chanthavanich1, P Nontasut, V Prarinyanuparp

  • 1Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

The Southeast Asian Journal of Tropical Medicine and Public Health
|June 1, 1989
PubMed

Insights

A second course of albendazole significantly improved cure rates for children with strongyloidiasis. This treatment is effective and safe for pediatric parasitic infections.

Area of Science:

  • Pediatric Infectious Diseases
  • Parasitology
  • Clinical Pharmacology

Background:

  • Strongyloidiasis is a parasitic infection affecting children globally.
  • Albendazole is a common anthelmintic drug used for treating helminthic infections.

Purpose of the Study:

  • To compare the efficacy of a single versus a repeated course of albendazole for treating strongyloidiasis in children.
  • To evaluate the safety and cure rates of different albendazole regimens.

Main Methods:

  • Fifty children diagnosed with strongyloidiasis were randomized into two groups.
  • Group I received a 3-day course of albendazole, while Group II received the same regimen repeated one week later.
  • Treatment success was determined by negative stool cultures performed post-treatment.

Main Results:

  • The cure rate for the single-course albendazole group (Group I) was 80.8%.
  • The cure rate for the two-course albendazole group (Group II) was 91.7%.
  • Both regimens showed minimal side effects, primarily mild, transient vomiting.

Conclusions:

  • A repeated course of albendazole demonstrated a higher cure rate for pediatric strongyloidiasis compared to a single course.
  • While not statistically significant in this study, the trend suggests a potential benefit of a second treatment course.
  • Albendazole is a safe and effective option for treating strongyloidiasis in children.

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