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GLUT-1 Expression in Cutaneous Basal and Squamous Cell Carcinomas
Asmaa Gaber Abdou1, Marwa Mohammad Serag Eldien2, Daliah Elsakka2
1Menoufia University, Shebein Elkom, Egypt Asmaa_elsaidy@yahoo.com.
International Journal of Surgical Pathology
|June 21, 2015
Summary
Glucose transporter 1 (GLUT-1) is overexpressed in common skin cancers, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). GLUT-1 expression is significantly higher in SCC and linked to tumor grade and differentiation.
Area of Science:
- Oncology
- Cell Biology
- Biochemistry
Background:
- Glucose uptake is regulated by facilitative glucose transporters (GLUTs).
- GLUT-1 is the primary glucose transporter in many human cells.
- Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are prevalent skin cancers.
Purpose of the Study:
- To evaluate the pattern and distribution of GLUT-1 in cutaneous BCC and SCC.
- To compare GLUT-1 expression between BCC and SCC.
- To investigate the relationship between GLUT-1 expression and clinicopathological features.
Main Methods:
- Immunohistochemistry was used to detect GLUT-1 expression.
- The study included 16 cases of BCC and 16 cases of SCC.
- Expression patterns, positivity, and percentage were analyzed.
Main Results:
- GLUT-1 was expressed in 100% of SCC and 62.5% of BCC.
- Membranous GLUT-1 staining was observed in 62.5% of SCC and 31.25% of BCC.
- Higher GLUT-1 positivity and percentage were found in SCC compared to BCC (P = .02, P = .000).
- Increased GLUT-1 expression correlated with high grade in SCC (P = .03).
- GLUT-1 was localized to the periphery of SCC nests and the center of BCC nests.
Conclusions:
- GLUT-1 is overexpressed in cutaneous non-melanoma skin cancers.
- GLUT-1 expression in SCC is associated with differentiation status.
- GLUT-1 expression in BCC is linked to squamous metaplastic areas.
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