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Immunohistochemical Expression of ROR2 in Gastrointestinal Stromal Tumor
Asmaa Gaber Abdou1, Mona Kandil2, Moshira Abd El Wahed2
1Pathology Department, Faculty of Medicine, Menoufia University, Shebein Elkom, Egypt. asmaa_elsaidy@yahoo.com.
Background:
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors affecting the digestive tract, comprising approximately 0.1-3% of all gastrointestinal cancers. ROR2, a member of the receptor tyrosine kinase orphan receptor subfamily, functions as a signaling receptor for Wnt ligands. This study aims to assess the prognostic significance of ROR2 expression in GIST.
Methods:
A total of 56 paraffin-embedded blocks of GIST cases originating from different parts of the gastrointestinal tract (GIT) were included in this study. Immunohistochemistry was performed to detect ROR2 expression.
Results:
ROR2 expression was observed in 71.4% of GIST cases, and strong intensity of ROR2 staining was significantly associated with prolonged overall survival of GIST patients (p = 0.048). Furthermore, ROR2 positivity and the percentage of immunostaining showed an inverse correlation with tumor progression.
Conclusions:
GIST cases displaying ROR2 positivity exhibit a reduced likelihood of disease progression and demonstrate favorable prognostic characteristics.
Insights
Gastrointestinal stromal tumor (GIST) patients with ROR2 expression show better survival rates. ROR2 positivity in GIST correlates with reduced tumor progression and favorable prognostic indicators.
Area of Science:
- Oncology
- Molecular Biology
- Gastroenterology
Background:
- Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the digestive tract, representing 0.1-3% of gastrointestinal cancers.
- ROR2, a receptor tyrosine kinase, is a signaling receptor for Wnt ligands, implicated in various cellular processes.
Purpose of the Study:
- To investigate the prognostic significance of ROR2 expression in GIST.
- To determine the association between ROR2 expression levels and patient survival and tumor progression.
Main Methods:
- Analysis of 56 paraffin-embedded GIST tissue samples from various gastrointestinal tract locations.
- Immunohistochemistry technique employed to detect and quantify ROR2 expression in GIST tissues.
Main Results:
- ROR2 expression was detected in 71.4% of GIST cases studied.
- Strong ROR2 staining intensity correlated significantly with prolonged overall survival (p=0.048).
- ROR2 positivity and higher immunostaining percentages inversely correlated with tumor progression.
Conclusions:
- GIST cases positive for ROR2 expression demonstrate a lower likelihood of disease progression.
- ROR2 positivity is associated with favorable prognostic characteristics in GIST patients.
