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Updated: Apr 9, 2026
07:41
Quantification of Levator Ani Hiatus Enlargement by Magnetic Resonance Imaging in Males and Females with Pelvic Organ Prolapse
Published on: April 17, 2019
10.6K
[Paradoxical sphincters in the abdomen]
1Chirurg. Univ.-Klinik Bonn, Zentrum für Chirurgie, Sigmund-Freud-Str. 25, 53127, Bonn-Venusberg, Deutschland, stel33345@aol.com.
Summary
Nitric oxide (NO) plays a crucial role in smooth muscle relaxation in various human body parts. This study highlights NO
Area of Science:
- Physiology
- Neurotransmission
- Smooth Muscle Biology
Context:
- Nitric oxide (NO) acts as a neurotransmitter, regulating smooth muscle tension.
- NO is vital for proper smooth muscle function in specific anatomical locations.
- Previous work established NO's role in esophageal sphincter mechanisms.
Purpose:
- To explore the role of nitric oxide-producing cells in various sphincter structures.
- To confirm the stretch sphincter mechanism of the lower esophageal sphincter.
- To investigate functional disturbances in the lower esophageal sphincter.
Summary:
- Nitric oxide-producing cells are found in the gastric fundus, anorectal, vesicourethral tract, and uterine cervix.
- These cells function within anatomical sphincter structures exhibiting paradoxical roles.
- High-resolution esophageal manometry can detect functional disturbances related to gastric plication.
Impact:
- Confirms the importance of the stretch sphincter mechanism in the lower esophageal sphincter.
- Provides insights into the treatment of gastroesophageal reflux disease (GERD).
- Demonstrates the utility of esophageal manometry in identifying sphincter dysfunction.
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