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Unravelling the Complexity and Functions of MTA Coregulators in Human Cancer

Da-Qiang Li1, Rakesh Kumar2

  • 1Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Key Laboratory of Breast Cancer in Shanghai, Shanghai Medical College, Fudan University, Shanghai, China; Key Laboratory of Epigenetics in Shanghai, Shanghai Medical College, Fudan University, Shanghai, China.

Advances in Cancer Research
|June 22, 2015
PubMed

Insights

Metastasis-associated protein 1 (MTA1) and its family members are key regulators of gene expression in cancer. Deregulation of MTA proteins impacts cancer progression, survival, and patient prognosis, offering therapeutic potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Gene Regulation

Background:

  • Metastasis-associated protein 1 (MTA1) identified ~20 years ago.
  • MTA family proteins (six members) are coregulators involved in chromatin remodeling and gene expression.
  • MTA proteins are frequently deregulated in various human cancers.

Purpose of the Study:

  • To review current understanding of MTA protein regulatory mechanisms in cancer.
  • To discuss the functional roles of MTA proteins in cancer progression.
  • To explore potential implications of MTA proteins in cancer biology and therapeutics.

Main Methods:

  • Review of experimental and clinical evidence.
  • Analysis of MTA protein deregulation in human cancers.
  • Discussion of MTA protein functions in cell survival and metastasis.

Main Results:

  • MTA proteins, especially MTA1, are frequently deregulated in diverse cancers.
  • MTA family proteins regulate cell survival, invasion, and metastasis.
  • MTA1 overexpression correlates with cancer aggressiveness and poorer patient prognosis.

Conclusions:

  • MTA proteins are critical signaling nodes in cancer progression.
  • Understanding MTA protein regulation is crucial for cancer biology.
  • MTA proteins represent potential targets for novel cancer therapeutics.
Keywords:
CancerGene transcriptionMetastasis-associated geneNuRD complex

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