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Updated: Apr 9, 2026
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
[PROSPECTS FOR THE TREATMENT OF IDIOPATHIC AND NEUROGENIC OVERACTIVE BLADDER]
Abstract:
Overactive bladder (OAB) is a common problem in modern population. The main line of medical treatment of this condition is the use of M-cholinoblockers. Solifenacin has shown high selectivity for the bladder in preclinical studies. Data on the efficacy and safety of high-dose (10 mg/day) of solifenacin are insufficient. The study was aimed to the comparative evaluation of the effectiveness and safety of solifenacin at a dose of 5 and 10 mg/day. The study included 28 patients (17 women and 11 men), mean age was 41.3±6.7 years. All patients were divided into two groups. In Group 1 included 12 patients with idiopathic overactive bladder, the Group 2 (n=16) - with neurogenic overactive bladder. Depending on the effect obtained, in some patients the dose was increased to 10 mg/day 1 month after starting treatment. The duration of treatment was 12 weeks. Application of solifenacin at a dose of 5 mg in patients with overactive bladder significantly reduces the severity of symptoms. Increasing the dose was required in 3 (25%) patients with idiopathic OAB and in 10 (62.5%) - with neurogenic OAB. Patients unsatisfied by therapy with solifenacin 5 mg/ day initially had more severe symptoms of the disease - significantly more urgency frequency, incontinence episodes, and nocturia. The use of high doses of solifenacin increased the effectiveness of treatment. Statistical significance was achieved for all parameters evaluated. Against the background of increasing doses, the number ofadverse effects may increase, but within a month of therapy in most cases they are reduced.
Insights
Increasing solifenacin dosage to 10 mg/day effectively treats overactive bladder (OAB) symptoms, especially in neurogenic OAB cases. Higher doses improve outcomes for patients unsatisfied with initial 5 mg/day treatment.
Area of Science:
- Urology
- Pharmacology
Background:
- Overactive bladder (OAB) is a prevalent condition impacting modern populations.
- M-cholinoblockers are the primary medical treatment for OAB.
- Solifenacin exhibits high selectivity for the bladder, but data on high-dose efficacy is limited.
Purpose of the Study:
- To comparatively evaluate the effectiveness and safety of solifenacin at 5 mg/day and 10 mg/day doses.
- To assess dose escalation in patients with idiopathic and neurogenic OAB.
Main Methods:
- A 12-week study involving 28 patients (17 women, 11 men) with OAB.
- Patients were divided into idiopathic (n=12) and neurogenic (n=16) OAB groups.
- Dose was increased to 10 mg/day if initial 5 mg/day treatment was insufficient.
Main Results:
- Solifenacin 5 mg/day significantly reduced OAB symptoms.
- Dose escalation to 10 mg/day was required for 25% of idiopathic OAB and 62.5% of neurogenic OAB patients.
- Patients needing dose increase had more severe initial symptoms (urgency, incontinence, nocturia).
- Higher solifenacin doses significantly improved all evaluated parameters.
- Adverse effects initially increased with higher doses but generally decreased within a month.
Conclusions:
- Solifenacin is effective in treating OAB symptoms at both 5 mg and 10 mg/day.
- Dose escalation to 10 mg/day is beneficial for patients with more severe or neurogenic OAB.
- The safety profile is acceptable, with most adverse effects diminishing over time.
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