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Outcome of the First wwPDB Hybrid/Integrative Methods Task Force Workshop
Andrej Sali1, Helen M Berman2, Torsten Schwede3
1Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, California Institute for Quantitative Biosciences, Byers Hall Room 503B, University of California, San Francisco, 1700 4(th) Street, San Francisco, CA 94158-2330, USA.
Structure (London, England : 1993)
|June 23, 2015
Summary
Experts convened to establish standards for biomolecular modeling. They discussed representing, validating, and archiving integrative models and associated data for structural biology.
Area of Science:
- Structural Biology
- Computational Biology
- Bioinformatics
Background:
- Biomolecular structures are increasingly determined using integrative modeling, combining diverse experimental data and theoretical information.
- The complexity of these models necessitates standardized approaches for their representation, validation, and deposition.
Purpose of the Study:
- To outline the proceedings and conclusions of the first wwPDB Hybrid/Integrative Methods Task Force Workshop.
- To address key questions regarding the future of structural biology concerning integrative models.
Main Methods:
- Convened experts from experimental structural biology, integrative modeling, visualization, and data archiving.
- Facilitated discussions on representation, validation, data archiving, and deposition of integrative models.
Main Results:
- Identified critical questions regarding the representation and validation of integrative models.
- Discussed requirements for archiving data and models, and accompanying information for publication.
Conclusions:
- The workshop highlighted the need for community consensus on standards for integrative structural biology.
- Recommendations are crucial for the consistent and reliable archiving and dissemination of biomolecular models.
