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Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
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CRISPR01:59

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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Updated: Sep 9, 2025

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis
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Updates to the CASP Infrastructure in 2024.

Andriy Kryshtafovych1, Maciej Milostan2, Marc F Lensink3

  • 1Genome Center, University of California, Davis, Davis, California, USA.

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|September 2, 2025
PubMed
Summary
This summary is machine-generated.

The Critical Assessment of Structure Prediction (CASP) data system was updated for CASP16, handling new categories and integrating with the Critical Assessment of Predicted Interactions (CAPRI) system to advance macromolecular structure prediction.

Keywords:
3D structure predictionCASP16RNA structurealternative conformationsprotein structureprotein–ligand complexes

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Area of Science:

  • Computational biology
  • Structural biology
  • Bioinformatics

Background:

  • The Critical Assessment of Structure Prediction (CASP) is a community experiment to assess the state-of-the-art in macromolecular structure prediction.
  • The CASP data management system requires continuous evolution to meet the demands of these experiments.

Purpose of the Study:

  • To detail the infrastructure enhancements for the CASP16 experiment.
  • To document the integration of CASP and CAPRI (Critical Assessment of PRedicted Interactions) systems.

Main Methods:

  • Expanding the CASP data handling infrastructure.
  • Incorporating support for newly introduced and pilot categories from CASP15.
  • Integrating the CASP and CAPRI data management systems.

Main Results:

  • The CASP data management system was successfully expanded for CASP16.
  • New categories and pilot categories from CASP15 are now fully supported.
  • The CASP and CAPRI systems are now integrated.

Conclusions:

  • The updated CASP data management system effectively supports the evolving needs of macromolecular structure prediction experiments.
  • The integration with CAPRI facilitates a more comprehensive assessment of predicted interactions alongside structure prediction.