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Related Concept Videos

Nuclear Protein Sorting01:34

Nuclear Protein Sorting

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Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...
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Regulation of Nuclear Protein Sorting01:45

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Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
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Additional Subnuclear Structures02:10

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The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
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Nuclear Localization Signals and Import01:46

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Proteins targeted to the nucleus carry short stretches of amino acid sequences called the nuclear localization signal or NLS. Classical nuclear localization signals are of two types: monopartite and bipartite NLS. Monopartite classical NLS (cNLS) consists of a single cluster of 4-8 amino acids. Bipartite cNLS consists of two clusters of  2-3 amino acids and a 9-12 residue long proline-rich linker bridging the two clusters. Signal clusters are rich in positively charged amino acids such as...
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Nuclear Export of mRNA02:31

Nuclear Export of mRNA

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Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
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Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
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Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

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LINC'ing form and function at the nuclear envelope.

Peter Meinke1, Eric C Schirmer1

  • 1Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.

FEBS Letters
|June 23, 2015
PubMed
Summary
This summary is machine-generated.

The nuclear envelope, reinforced by the LINC complex, acts as a dynamic yet stable structure. This complex connects internal and external filament systems, enabling adaptability and communication.

Keywords:
LINC complexNesprin proteinNuclear envelopeNuclear envelope transmembrane proteinSUN protein

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Area of Science:

  • Cell Biology
  • Biophysics

Background:

  • The nuclear envelope is a complex structure with mechanical properties.
  • It features filament systems and nuclear pore complexes for regulation and communication.

Purpose of the Study:

  • To elucidate the structural organization of the LINC complex.
  • To understand how its organization contributes to the dynamic yet stable properties of the nuclear envelope.

Main Methods:

  • Analysis of recent findings on LINC complex structure.
  • Investigating the roles of coiled-coils, intrinsic disorder/order, and tissue-specific components.

Main Results:

  • The LINC complex connects the nucleoskeleton to cytoplasmic filament systems.
  • Its structure involves a combination of double- and triple-helical coiled-coils, intrinsic disorder and order, and tissue-specific components.

Conclusions:

  • The LINC complex's unique structural organization underlies the nuclear envelope's dynamic and stable characteristics.
  • This organization allows for simultaneous roles as structural support and communication pathways.