Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Larynx01:21

Larynx

6.4K
The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
6.4K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

4.9K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
4.9K
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

1.3K
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
1.3K
The Citric Acid Cycle: Overview01:37

The Citric Acid Cycle: Overview

24.5K
In aerobic organisms, the citric acid cycle is the second stage of cellular respiration wherein molecules derived from the breakdown of carbohydrates, proteins, and fats are oxidized into carbon dioxide and energy. This process is also known as the tricarboxylic acid (TCA) cycle as the first product of the cycle, citric acid, contains three carboxyl groups in its structure. Alternatively, this cycle is also referred to as the Krebs cycle, in honor of its discoverer Sir Hans Krebs.
The citric...
24.5K
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

1.6K
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
1.6K
Clinical Trials: Overview01:11

Clinical Trials: Overview

5.5K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of inflammatory markers in oral squamous cell carcinoma - A prognostic systematic literature review with emphasis on gingival squamous cell carcinoma.

Journal of oral and maxillofacial pathology : JOMFP·2026
Same author

Evaluation of Oxidative Stress Marker 4-hydroxynonenal in Oral Submucous Fibrosis: An Immunohistochemical Study.

Annals of African medicine·2026
Same author

Assessment of Immunohistochemical Expression of Lipid Peroxidation Marker 4-hydroxynonenal in Oral Lichen Planus - A Retrospective Study.

Annals of African medicine·2026
Same author

Assessment of immunohistochemical expression of oxidative stress marker 8-OHdG in oral lichen planus.

Nucleosides, nucleotides & nucleic acids·2025
Same author

Evaluation of the Immunohistochemical Expression of Lipid Peroxidation Marker 4-HNE and Comparison of the Expression in Various Histopathological Grades of Oral Squamous Cell Carcinoma.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals·2025
Same author

Evaluation of the immunohistochemical expression of oxidative DNA damage marker 8-OHdG in oral cancer.

Journal of oral and maxillofacial pathology : JOMFP·2025

Related Experiment Video

Updated: Apr 8, 2026

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
10:16

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

7.7K

Loricrin - an overview.

S Nithya1, T Radhika1, Nadeem Jeddy1

  • 1Department of Oral Pathology and Microbiology, Thai Moogambigai Dental College and Hospital, Chennai, Tamil Nadu, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|June 23, 2015
PubMed
Summary
This summary is machine-generated.

Loricrin, a key structural protein in the skin barrier, is crucial for epidermal health. Its altered expression may indicate early stages of oral potentially malignant disorders, suggesting its use as a diagnostic marker.

Keywords:
Cornified cell envelopeloricrinloricrin keratodermaoral sub mucous fibrosis

More Related Videos

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
07:36

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

2.0K
Establishment, Maintenance, Differentiation, Genetic Manipulation, and Transplantation of Mouse and Human Lacrimal Gland Organoids
10:49

Establishment, Maintenance, Differentiation, Genetic Manipulation, and Transplantation of Mouse and Human Lacrimal Gland Organoids

Published on: February 3, 2023

3.8K

Related Experiment Videos

Last Updated: Apr 8, 2026

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry
10:16

SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry

Published on: January 6, 2017

7.7K
Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
07:36

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

2.0K
Establishment, Maintenance, Differentiation, Genetic Manipulation, and Transplantation of Mouse and Human Lacrimal Gland Organoids
10:49

Establishment, Maintenance, Differentiation, Genetic Manipulation, and Transplantation of Mouse and Human Lacrimal Gland Organoids

Published on: February 3, 2023

3.8K

Area of Science:

  • Biochemistry
  • Dermatology
  • Cell Biology

Background:

  • Loricrin is a major structural protein forming the cornified envelope in terminally differentiating epidermal cells.
  • It plays a vital role in the skin's protective barrier function within the stratum corneum.
  • Loricrin expression is high in humid tissues and certain stratified epithelia, but absent in non-keratinizing epithelia.

Purpose of the Study:

  • To review the structure and function of loricrin.
  • To explore the significance of loricrin expression in various tissues.
  • To investigate the potential of loricrin as an early diagnostic marker for potentially malignant disorders.

Main Methods:

  • Literature review of existing studies on loricrin.
  • Analysis of loricrin's role in epidermal and oral mucosal tissues.
  • Examination of loricrin alterations in disease states.

Main Results:

  • Loricrin constitutes over 70% of the cornified envelope, essential for barrier integrity.
  • Expression patterns vary across mammalian stratified epithelia, with highest levels in humid environments.
  • Absence or altered expression of loricrin is noted in specific conditions.

Conclusions:

  • Loricrin's structural role is fundamental to epithelial barrier function.
  • Understanding loricrin expression provides insights into tissue defense mechanisms.
  • Loricrin shows potential as a biomarker for early detection of oral potentially malignant disorders like oral submucous fibrosis and leukoplakia.