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Fixed drug eruptions with intraoral presentation.
Rahul Srivastava1, Manorama Bihari2, Jyoti Bhuvan3
1Department of Oral Medicine and Radiology, Rama Dental College Hospital and Research Centre, Kanpur, India.
Indian Journal of Dentistry
|June 23, 2015
Summary
Fixed-drug eruption (FDE) is a rare adverse drug reaction. A case report details intraoral FDEs appearing after a single dose of ornidazole in a 58-year-old male.
Area of Science:
- Dermatology
- Pharmacology
- Immunology
Background:
- Fixed-drug eruption (FDE) is characterized as a rare, delayed-type hypersensitivity adverse drug reaction.
- FDE lesions characteristically recur at the same cutaneous site upon re-exposure to the causative agent.
Observation:
- A case report details a 58-year-old male patient presenting with intraoral lesions.
- These lesions developed following the initial dose of ornidazole, an antibiotic medication.
Findings:
- The patient experienced intraoral fixed-drug eruptions (FDEs).
- The reaction occurred after the very first administration of ornidazole, challenging typical FDE onset patterns.
Implications:
- This case highlights the potential for ornidazole to induce FDEs, even after a single dose.
- It underscores the importance of considering FDEs in the differential diagnosis of intraoral lesions, especially with a history of drug intake.
- Further investigation into the immunopathogenesis of ornidazole-induced FDEs may be warranted.
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