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An enterovirus 71 strain causes skeletal muscle damage in infected mice

Peixin Lin1, Lulu Gao1, Yeen Huang1

  • 1Department of Pathology, School of Basic Medical Sciences, Southern Medical University Tonghe, Guangzhou, China.

International Journal of Clinical and Experimental Pathology
|June 23, 2015
PubMed
Abstract

Insights

Enterovirus 71 (EV71) primarily targets skeletal muscles in young mice, leading to muscle damage and neurological symptoms like paralysis. This highlights the myotropic nature of EV71 infection.

Area of Science:

  • Virology
  • Pathology
  • Neurology

Background:

  • Enterovirus 71 (EV71) is a significant human pathogen causing a range of illnesses, from mild febrile disease to severe neurological complications.
  • Understanding the tissue tropism of EV71 is crucial for elucidating its pathogenesis and developing effective therapeutic strategies.

Purpose of the Study:

  • This study aimed to identify the primary target organs of EV71 in experimentally infected suckling mice.
  • The research specifically investigated the tropism of a particular EV71 clinical isolate.

Main Methods:

  • Suckling BALB/c mice (5 days old) were inoculated with an EV71 strain.
  • Infected mice underwent comprehensive histopathological examination, including immunohistochemistry, in situ hybridization, and ultrastructural analysis.

Main Results:

  • Mice exhibited clinical signs such as limb paralysis, ataxia, and loss of balance.
  • Histopathological findings revealed a high viral load of EV71 within skeletal muscle tissues.
  • Skeletal muscle damage correlated directly with the presence of the virus.

Conclusions:

  • The EV71 clinical isolate demonstrated significant myotropism, indicating a preference for muscle tissue.
  • Skeletal muscles were identified as key target organs for EV71 in this suckling mouse model.
  • Further research into the EV71-muscle disease relationship is warranted to better understand EV71 pathogenesis.
Keywords:
BALB/c miceEnterovirus 71histopathological examinationmitochondrial injurymyotropismskeletal muscle damage

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