[A case of active tertiary syphilis].

Area of Science:

• Infectious Diseases
• Dermatology
• Neurology

Background:

• Syphilis is a sexually transmitted infection caused by *Treponema pallidum*.
• Tertiary syphilis represents the late stage of infection, potentially causing severe neurological and cardiovascular complications.
• Untreated syphilis can progress through stages, with tertiary manifestations appearing years after initial infection.

Observation:

• A 41-year-old male patient with no prior specific treatment presented with symptoms of tertiary active syphilis.
• Clinical manifestations were extensive and appeared without obvious precipitating factors.
• Notably, the patient exhibited no visceral abnormalities despite the advanced stage of the disease.

Findings:

• The case highlights the potential for extensive cutaneous and/or neurological involvement in untreated tertiary syphilis.
• Absence of visceral compromise in this specific case provides a unique clinical observation.
• This presentation underscores the varied clinical spectrum of late-stage syphilis.

Implications:

• This case emphasizes the importance of recognizing diverse clinical presentations of tertiary syphilis, even in the absence of visceral involvement.
• It suggests that prompt diagnosis and treatment remain crucial to prevent potentially devastating long-term complications.
• Further research into factors influencing disease manifestation and progression in tertiary syphilis is warranted.