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Cyclosporin A and psoriasis: a thermographic study
F Ippolito1, A Di Carlo, M Carducci
1Istituto Dermatologico S. Maria e S. Gallicano, Rome, Italy.
Acta Dermato-Venereologica. Supplementum
|January 1, 1989
Summary
This study used thermography to assess skin blood flow in psoriasis patients. Cyclosporin therapy improved skin condition by prolonging thermal recovery times, indicating enhanced blood flow regulation.
Area of Science:
- Dermatology
- Physiology
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Cutaneous blood flow alterations are observed in psoriatic skin.
- Thermography offers a non-invasive method to evaluate skin microcirculation.
Purpose of the Study:
- To investigate changes in psoriatic skin blood flow using thermography.
- To assess the impact of cyclosporin therapy on cutaneous hemodynamics in psoriasis patients.
Main Methods:
- Utilized a thermographic method to measure thermal recovery times after controlled cold stimulation (5°C for 20 sec).
- Evaluated 7 patients with psoriasis, comparing measurements before and after a course of cyclosporin treatment.
- Included measurements on healthy perilesional skin for comparison.
Main Results:
- Psoriatic skin exhibited initial hyperthermia and faster thermal recovery compared to healthy skin.
- Cyclosporin therapy led to a prolonged thermal recovery time in all treated patients.
- A significant clinical improvement of the dermatosis was observed concurrently with prolonged recovery times.
Conclusions:
- Thermography effectively quantifies changes in cutaneous blood flow in psoriasis.
- Cyclosporin therapy positively modulates skin microcirculation in psoriatic patients.
- Prolonged thermal recovery time is a potential indicator of therapeutic efficacy in psoriasis.