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Membrane fluidity changes in polymorphonuclear leukocytes and erythrocytes in psoriasis
A M Offidani1, O Simonetti, G Ferretti
1Institute of Dermatology, School of Medicine, University of Ancona, Italy.
Abstract:
We studied membrane fluidity in living polymorphonuclear leukocytes and in erythrocytes of 8 psoriatic patients, using fluorescence polarization of 1-(4-trimethylaminophenyl)-6-phenyl-1,3,5-hexatriene. In erythrocyte membranes of psoriatic patients we observed a decrease of fluidity, these changes were not associated to relevant modifications of the cholesterol to phospholipid molar ratio. Moreover, we observed a decrease in polymorphonuclear leukocytes membrane fluidity. Our results indicate changes in membrane fluidity involving membranes different from the epidermal cells and suggest the hypothesis of a defect in membrane-cytoskeleton interactions in psoriasis.