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[Optic disc measurements with computerized image analysis in experimental chronic glaucoma].

M Shirakashi, K Nanba, K Iwata

    Nippon Ganka Gakkai Zasshi
    |August 1, 1989
    PubMed
    Summary

    Glaucoma research in monkeys shows that sustained high intraocular pressure (IOP) causes significant optic disc cupping. The degree of optic disc damage, including increased cup-to-disc ratio, correlates with IOP elevation, aiding glaucoma research.

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    Area of Science:

    • Ophthalmology
    • Glaucoma Research
    • Animal Models

    Context:

    • Glaucoma is a leading cause of irreversible blindness worldwide.
    • Understanding the morphological changes in the optic disc is crucial for diagnosing and managing glaucoma.
    • Animal models provide valuable insights into disease mechanisms and progression.

    Purpose:

    • To quantitatively analyze the morphological changes of the optic disc in Japanese monkey eyes with sustained elevated intraocular pressure (IOP).
    • To investigate the correlation between the degree of IOP elevation and optic disc cupping.
    • To evaluate the utility of computerized image analysis for monitoring experimental glaucoma.

    Summary:

    • Ten Japanese monkey eyes underwent sustained IOP elevation induced by argon laser trabeculoplasty.

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  • Morphological parameters including cup-disc ratio (CDR), disc area (DA), cup volume/disc area (CV/DA), and rim area/disc area (RA/DA) were measured using a computerized image analyzer.
  • In advanced glaucoma (approx. 1 year), CV/DA increased 4.96x, vertical CDR 1.78x, horizontal CDR 1.69x, DA 1.42x, and RA/DA decreased 0.54x.
  • Significant positive correlations were observed between the IOP ratio and vertical CDR (gamma=0.65) and CV/DA (gamma=0.68).

    • Impact:

    • The study demonstrates that glaucomatous optic disc cupping in monkey eyes correlates with the degree of IOP elevation.
    • Quantitative, longitudinal follow-up of optic disc changes in experimental glaucoma models can enhance understanding of human glaucomatous optic nerve damage.
    • Findings support the use of advanced imaging techniques for glaucoma research and monitoring.