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Development of SHIVs with circulating, transmitted HIV-1 variants

Amit Sharma1, David F Boyd1,2, Julie Overbaugh1

  • 1Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Journal of Medical Primatology
|June 24, 2015
PubMed
Summary

The simian-human immunodeficiency virus (SHIV)/macaque model is vital for pre-clinical HIV-1 research. Rational SHIV design using transmitted HIV-1 variants improves prediction of human interventions for vaccine and prevention strategies.

Keywords:
HIV-1 envelopeSHIV/macaque modeltransmitted/founder HIV-1

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