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Related Concept Videos

Blood Pressure Imbalances and Circulatory Shock01:24

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Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
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Updated: Apr 8, 2026

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care
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Microcirculatory disorders during septic shock.

Hafid Ait-Oufella1, Simon Bourcier, Sophie Lehoux

  • 1aAP-HP, Hôpital Saint-Antoine, Service de réanimation médicale, Paris bUniversité Pierre et Marie Curie cInserm U970, Centre de recherche cardiovasculaire de Paris (PARCC), Paris, France dLady Davis Institute, McGill University, Montréal, Canada eInserm U1136, Paris, France.

Current Opinion in Critical Care
|June 24, 2015
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Summary
This summary is machine-generated.

Despite advances in septic shock treatment, mortality remains high. Understanding microcirculatory disorders is key to improving patient outcomes and managing this critical condition.

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Area of Science:

  • Critical Care Medicine
  • Physiology
  • Vascular Biology

Background:

  • Septic shock continues to have high mortality rates despite 20 years of treatment advancements.
  • Microcirculatory dysfunction is increasingly recognized as a critical factor in septic shock pathophysiology.

Purpose of the Study:

  • To review the current understanding of microcirculatory disorders in septic shock.
  • To highlight the importance of microcirculation in predicting patient prognosis and guiding management.

Main Methods:

  • Analysis of experimental and clinical studies focusing on microcirculatory blood flow.
  • Identification of alterations in small blood vessels in septic shock patients.

Main Results:

  • Microcirculatory abnormalities in septic shock are early, heterogeneous, and linked to organ failure.
  • These anomalies vary significantly between patients and cannot be predicted by global hemodynamic parameters alone.

Conclusions:

  • Microcirculatory disorders are central to septic shock pathophysiology and strongly correlate with patient prognosis.
  • Integrating tissue perfusion parameters into septic shock management is crucial for improving patient outcomes.