Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

358
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
358
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

814
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
814
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

327
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
327
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

338
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
338
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

323
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
323
Development of Human Microbiota01:30

Development of Human Microbiota

39
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
39

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Palpebral ophthalmomyiasis: Case report].

Journal francais d'ophtalmologie·2024
Same author

Health and security risks of humanitarian aid workers during field missions: Experience of the International Red Cross.

Travel medicine and infectious disease·2022
Same author

Operational considerations for the management of non-communicable diseases in humanitarian emergencies.

Conflict and health·2021
Same author

Diagnostic approach to encephalitis and meningoencephalitis in adult returning travellers.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
Same author

Diagnostic tools to tackle infectious causes of encephalitis and meningoencephalitis in immunocompetent adults in Europe.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
Same author

Addressing the needs of terminally-ill patients in Bosnia-Herzegovina: patients' perceptions and expectations.

BMC palliative care·2018

Related Experiment Video

Updated: Apr 8, 2026

Oral Health Assessment by Lay Personnel for Older Adults
08:47

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

13.9K

[Elderly travellers: review and advices].

G Eperon, F Chappuis

    Revue Medicale Suisse
    |June 25, 2015
    PubMed
    Summary

    Elderly travelers require tailored pre-travel consultations. These consultations should address pre-existing conditions and medication adjustments to prevent travel-related health complications.

    Area of Science:

    • Geriatric Medicine
    • Travel Medicine
    • Public Health

    Context:

    • Increasing global travel among the elderly population.
    • Unique health considerations for older travelers.
    • Link between underlying health conditions and travel risks.

    Purpose:

    • To adapt pre-travel consultations for elderly individuals.
    • To evaluate risks of pre-existing condition decompensation during travel.
    • To optimize medication management and healthcare access for traveling seniors.

    Summary:

    • Elderly travelers, while not inherently more susceptible to illness, face increased risks of complications from travel-related diseases due to pre-existing conditions.
    • Pre-travel consultations for seniors must extend beyond standard advice to include comprehensive risk assessment for comorbidities.

    More Related Videos

    Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
    07:21

    Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease

    Published on: June 16, 2023

    1.7K
    Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
    12:59

    Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

    Published on: July 5, 2017

    13.4K

    Related Experiment Videos

    Last Updated: Apr 8, 2026

    Oral Health Assessment by Lay Personnel for Older Adults
    08:47

    Oral Health Assessment by Lay Personnel for Older Adults

    Published on: February 2, 2020

    13.9K
    Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
    07:21

    Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease

    Published on: June 16, 2023

    1.7K
    Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
    12:59

    Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

    Published on: July 5, 2017

    13.4K
  • Management strategies should involve adapting medications and planning for acute care needs during travel.

    • Impact:

    • Improved health outcomes for elderly travelers.
    • Reduced incidence of severe travel-associated illness complications in older adults.
    • Enhanced preparedness of healthcare providers for geriatric travel medicine.