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[A case of recurrent aseptic meningitis induced by ergot agents]
Tomoko Ogawa1, Asako Tagawa, Ritsuo Hashimoto
1Department of Neurology, International University of Health and Welfare Hospital.
Abstract:
We describe the case of a 29-year-old woman with recurrent aseptic meningitis that was caused by ergot agents. She miscarried at age 27, and the uterus constrictor methylergometrine was prescribed. Three days later, she developed aseptic meningitis and was hospitalized. Two years later, she again developed aseptic meningitis the day after she took ergotamine tartrate. In both events, her symptoms improved rapidly when the medication was stopped. The drug-induced lymphocyte stimulation test for methylergometrine yielded a value of 180%. Drug-induced meningitis is a rare form of recurrent aseptic meningitis. Many studies have reported cases of meningitis caused by non-steroidal anti-inflammatory drugs, but many other drugs can induce aseptic meningitis. To the best of our knowledge, this is the first case of aseptic meningitis induced by ergot agents.
Insights
Recurrent aseptic meningitis was linked to ergot agents in a 29-year-old woman. Symptoms resolved upon medication cessation, highlighting a rare drug-induced meningitis cause.
Area of Science:
- Neurology
- Toxicology
- Pharmacology
Background:
- Aseptic meningitis is an inflammation of the membranes surrounding the brain and spinal cord.
- Drug-induced meningitis is a rare but serious condition.
- Ergot agents are commonly used for postpartum hemorrhage and migraine treatment.
Observation:
- A 29-year-old woman experienced recurrent aseptic meningitis following exposure to ergot agents.
- The first episode occurred after methylergometrine use for miscarriage, and the second after ergotamine tartrate ingestion.
- Symptoms in both instances rapidly improved after discontinuing the suspected medications.
Findings:
- A drug-induced lymphocyte stimulation test was positive for methylergometrine (180%).
- This case represents the first documented instance of aseptic meningitis induced by ergot agents.
- While non-steroidal anti-inflammatory drugs are common causes, other medications can also trigger this condition.
Implications:
- Clinicians should consider ergot agents in the differential diagnosis of recurrent aseptic meningitis.
- Awareness of this potential adverse effect can prevent misdiagnosis and ensure prompt treatment.
- Further research may elucidate the specific mechanisms of ergot-induced meningitis.
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