Exosomes released by keratinocytes modulate melanocyte pigmentation
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Updated: Apr 8, 2026

Feeder-free Derivation of Melanocytes from Human Pluripotent Stem Cells
Published on: March 3, 2016
Alessandra Lo Cicero1, Cédric Delevoye2, Floriane Gilles-Marsens2
11] Institut Curie, PSL Research University, UMR144, CNRS, F-75248 Paris, France [2] Structure and Membrane Compartments, Centre National de la Recherche Scientifique, UMR144, Paris F-75248, France [3] Cell and Tissue Imaging Facility, Infrastructures en Biologie Santé et Agronomie (IBiSA), Paris F-75248, France.
Abstract:
Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids and RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes and melanocytes in the epidermis. Here we report that exosomes secreted by keratinocytes enhance melanin synthesis by increasing both the expression and activity of melanosomal proteins. Furthermore, we show that the function of keratinocyte-derived exosomes is phototype-dependent and is modulated by ultraviolet B. In sum, this study uncovers an important physiological function for exosomes in human pigmentation and opens new avenues in our understanding of how pigmentation is regulated by intercellular communication in both healthy and diseased states.
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