Related Experiment Video
Updated: Apr 8, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
3-Epi-25 hydroxyvitamin D in pregnancy.
S E Bennett1, C Casey1, J McPeake1
1Queen's University Belfast, United Kingdom.
This study found that 3-epi-25OHD levels vary seasonally in pregnant women and correlate with 25OHD. In women with type 1 diabetes, 3-epi-25OHD is linked to glycaemic control and is affected by maternal BMI.
Area of Science:
- Endocrinology
- Nutritional Science
- Reproductive Health
Background:
- The physiological role of 3-epi-25OHD (C3 epimers of vitamin D) remains unclear.
- Limited data exists on 3-epi-25OHD levels in human populations, particularly during pregnancy.
Purpose of the Study:
- To quantify 3-epi-25OHD levels in non-diabetic and type 1 diabetes mellitus (T1DM) pregnancies.
- To investigate the relationship between 25OHD and 3-epi-25OHD.
- To assess maternal body mass index (BMI) impact on 3-epi-25OHD and its association with glycaemic control markers.
Main Methods:
- An observational study involving 52 pregnant controls and 65 pregnant women with T1DM.
- Measurement of 25OHD and 3-epi-25OHD using liquid chromatography tandem mass spectrometry.
Main Results:
- 3-Epi-25OHD was detected in over 90% of participants, with higher median levels in T1DM pregnancies.
- Maternal and cord 3-epi-25OHD levels significantly correlated with 25OHD and showed seasonal variations.
- In T1DM pregnancies, 3-epi-25OHD negatively correlated with HbA1c and was negatively impacted by maternal BMI >30kg/m².
Conclusions:
- Maternal 3-epi-25OHD levels display seasonal patterns and correlate with 25OHD in both diabetic and non-diabetic pregnancies.
- 3-Epi-25OHD in T1DM pregnancies is associated with glycaemic control, suggesting a potential clinical relevance.
More Related Videos
06:47Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
12:17The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
Related Concept Videos
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
Teratogenicity
Connective Tissue Cell Types
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...