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Tedizolid: The First Once-Daily Oxazolidinone Class Antibiotic
Steven D Burdette1, Robin Trotman2
1Wright State University Boonshoft School of Medicine, Dayton, Ohio.
Summary
Tedizolid is a novel oxazolidinone antibiotic approved for skin infections. Clinical trials show it is noninferior to linezolid with a shorter duration and fewer side effects.
Area of Science:
- Pharmacology
- Infectious Diseases
- Clinical Trials
Background:
- Tedizolid phosphate is a once-daily oxazolidinone antibiotic prodrug.
- It is converted to active tedizolid, effective against Gram-positive pathogens like MRSA.
- Tedizolid is approved for acute bacterial skin and skin structure infections (ABSSSI).
Purpose of the Study:
- To evaluate the efficacy and safety of tedizolid in treating ABSSSI.
- To compare tedizolid's effectiveness and side effect profile against linezolid.
Main Methods:
- Two randomized controlled phase 3 trials were conducted.
- Participants received either 6 days of tedizolid (200 mg once daily) or 10 days of linezolid (600 mg twice daily).
Main Results:
- Tedizolid demonstrated noninferiority to linezolid in treating ABSSSI.
- Tedizolid showed a different incidence of gastrointestinal and hematologic side effects compared to linezolid.
- Tedizolid appears to lack drug interactions with SSRIs.
Conclusions:
- Tedizolid is a viable alternative to linezolid for ABSSSI treatment.
- The shorter dosing regimen and potentially improved side effect profile of tedizolid are significant advantages.
- Further studies are evaluating tedizolid for other infections.
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