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Tedizolid: The First Once-Daily Oxazolidinone Class Antibiotic

Steven D Burdette1, Robin Trotman2

  • 1Wright State University Boonshoft School of Medicine, Dayton, Ohio.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|June 25, 2015
PubMed

Insights

Tedizolid is a novel oxazolidinone antibiotic approved for skin infections. Clinical trials show it is noninferior to linezolid with a shorter duration and fewer side effects.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Clinical Trials

Background:

  • Tedizolid phosphate is a once-daily oxazolidinone antibiotic prodrug.
  • It is converted to active tedizolid, effective against Gram-positive pathogens like MRSA.
  • Tedizolid is approved for acute bacterial skin and skin structure infections (ABSSSI).

Purpose of the Study:

  • To evaluate the efficacy and safety of tedizolid in treating ABSSSI.
  • To compare tedizolid's effectiveness and side effect profile against linezolid.

Main Methods:

  • Two randomized controlled phase 3 trials were conducted.
  • Participants received either 6 days of tedizolid (200 mg once daily) or 10 days of linezolid (600 mg twice daily).

Main Results:

  • Tedizolid demonstrated noninferiority to linezolid in treating ABSSSI.
  • Tedizolid showed a different incidence of gastrointestinal and hematologic side effects compared to linezolid.
  • Tedizolid appears to lack drug interactions with SSRIs.

Conclusions:

  • Tedizolid is a viable alternative to linezolid for ABSSSI treatment.
  • The shorter dosing regimen and potentially improved side effect profile of tedizolid are significant advantages.
  • Further studies are evaluating tedizolid for other infections.
Keywords:
ABSSSIMRSAlinezolidoxazolidinonetedizolid

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