Related Experiment Video
Updated: Apr 8, 2026

Functional Cloning Using a Xenopus Oocyte Expression System
Published on: January 30, 2016
The Origin, Expression, Function and Future Research Focus of a G Protein-coupled Receptor, Mas-related Gene X2
Haihui Wu1, Meiqi Zeng2, Eric Y P Cho3
1Department of Medicine, Shenzhen University Health Science Centre, Shenzhen, China; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Abstract:
Mas-related genes (Mrgs) belong to a large family of G protein-coupled receptor genes found in rodents. Human MRGX proteins are G protein-coupled 7-transmembrane proteins sharing 41-52% amino acid identity with each other, but have no orthologs in rodents. MrgX2 is a member of the MrgX family. MRGX2 is expressed in the small neurons of sensory ganglia and mast cells. It can interact with a series of factors and genes such as the peptides substance P, vasoactive intestinal peptide, cortistatin (CST), proadrenomedullin N-terminal peptide (PAMP), LL-37, PMX-53 and β-defensins. MRGX2 is related to nociception, adrenal gland secretion and mast cell degranulation. Recent research on MrgX2 provides insights into its role in nociception and anti-microbial activities. This article reviewed the origin, expression and function of MrgX2, and discussed possible future research focus.
Related Concept Videos
Reporter Genes
Regulation of Expression at Multiple Steps
Master Transcription Regulators
Regulation of Expression Occurs at Multiple Steps
Regulation of Expression Occurs at Multiple Steps
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
Inheritance of Chromatin Structures

