[Hypoplastic dysplasia as one of the forms of nephropathy]

Hereditary and congenital nephropathies constitute a substantial proportion among diseases of the urinary system. Renal biopsies from 3 patients showing clinical symptoms of chronic glomerulonephritis were examined. Morphological studies were made of semithin and serial ultrathin sections of the biopsy specimens. This revealed the racemosely arranged glomeruli with single capillary loops, abundant rounded cells freely lying in the cavity of a capsule; single mesangial cells; irregular enlargement, loosening, and thinning of the basement membrane. The analysis of the findings makes it possible to consider them to be a manifestation of hypoplastic dysplasia, to differentiate nephropathy developing at this background from other renal diseases and to use a more efficient and sparing therapy.