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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
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Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
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Oligosaccharide Assembly01:24

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Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
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Polysaccharide-Based Conjugates for Biomedical Applications.

Arijit Basu1,2, Konda Reddy Kunduru1, Ester Abtew1

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Bioconjugate Chemistry
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Summary
This summary is machine-generated.

Polysaccharide conjugates, leveraging functional groups, offer biocompatible solutions for drug delivery and tissue engineering. Modern advancements enable responsive and targeted applications in biomedical fields.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Polysaccharides possess diverse functional groups (hydroxyl, amino, carboxylic acid, aldehydes) enabling conjugation.
  • Key properties include biodegradability, biocompatibility, and hydrophilicity.
  • Polysaccharide conjugates are established in drug/gene delivery, tissue engineering, and solubilizing hydrophobic compounds.

Purpose of the Study:

  • To review polysaccharides and their conjugation strategies.
  • To compile recent applications of polysaccharide conjugates.
  • To highlight advancements in polysaccharide conjugate design.

Main Methods:

  • Introduction to various polysaccharides.
  • Discussion of synthetic strategies for polysaccharide conjugation.
  • Compilation and analysis of recent literature on applications.

Main Results:

  • Polysaccharide conjugates are versatile for biomedical applications.
  • Functional groups facilitate conjugation for tailored properties.
  • Modern conjugates exhibit responsiveness (thermo-, pH-, photo-) and target specificity.

Conclusions:

  • Polysaccharide conjugates are crucial in advanced biomedical applications.
  • Synthetic strategies enable the development of sophisticated, responsive, and targeted conjugates.
  • The field is rapidly evolving, driven by nanotechnology and gene/tissue engineering.