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Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Apr 8, 2026

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders

Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders

Published on: May 31, 2024

Characterizing Resting-State Brain Function Using Arterial Spin Labeling.

J Jean Chen^1,2, Kay Jann³, Danny J J Wang³

¹1 Rotman Research Institute, Baycrest Centre for Geriatric Care , Toronto, Canada .

Brain Connectivity

|June 25, 2015

Summary

This summary is machine-generated.

Arterial spin labeling (ASL), a magnetic resonance imaging (MRI) method, offers a viable alternative to BOLD for assessing resting-state brain function and connectivity. ASL provides insights into cerebral blood flow, network activity, and metabolism, advancing neuroscience research.

Keywords:

arterial transit time arterial-spin labeling cerebral blood flow functional connectivity functional magnetic resonance imaging neurovascular coupling perfusion water permeability

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Area of Science:

Neuroimaging
Physiology
Magnetic Resonance Imaging

Background:

Arterial spin labeling (ASL) is an established MRI technique for brain studies.
Its application in assessing resting-state brain function is expanding.
This review focuses on ASL's role in evaluating brain activity without task-based paradigms.

Purpose of the Study:

To review the application of ASL in assessing resting-state brain function.
To explore ASL as an alternative to BOLD for functional connectivity (FC) measurements.
To discuss ASL's utility in studying network cerebral blood flow (CBF), dynamic CBF-BOLD coupling, and cerebral metabolism.

Main Methods:

Review of existing literature on ASL for resting-state brain function.
Discussion of ASL-based cerebral blood flow (CBF) measurements for FC.
Analysis of ASL for assessing network CBF, dynamic CBF-BOLD coupling, and metabolism.

Main Results:

ASL provides an alternative to BOLD for resting-state FC measurement.
Network CBF derived from ASL can serve as a surrogate for metabolic activity.
ASL enables the study of dynamic CBF-BOLD coupling and oxidative metabolism.

Conclusions:

ASL is a viable MRI technique for studying resting-state brain function.
It holds significant translational value for both healthy and diseased brain research.
Future directions include advancements in imaging speed and addressing motion artifacts.