Vascular effects of naftidrofuryl in a randomized placebo-controlled double-blind study

In a randomized, placebo-controlled, double-blind, crossover study in 10 volunteers it was demonstrated that intravenous administration of 200 mg naftidrofuryl (Dusodril, Praxilene) produced a slight but significant increase in the erythrocyte column diameters of conjunctival arterioles (mean diameter 17.5 +/- 7.6 microns) of 6.9% which persisted until 1 h after administration. The venules (mean diameter of the erythrocyte column 35.4 +/- 11.5 microns) are not significantly affected at the concentration tested. In their time course the results are in good agreement with the former measurements of the peripheral resistance and with the kinetic characteristic of the drug.