Internalization, Trafficking, Intracellular Processing and Actions of Antibody-Drug Conjugates
1Scientific Development Manager, Discovery Biology, GenScript USA Inc., 860 Centennial Ave., Piscataway, New Jersey, 08854, USA. ben.xu@genscript.com.
Purpose:
This review discusses the molecular mechanism involved in the targeting and delivery of antibody-drug conjugates (ADCs), the new class of biopharmaceuticals mainly designed for targeted cancer therapy.
Methods:
this review goes over major progress in preclinical and clinical studies of ADCs, in the past 5 years.
Results:
The pharmacokinetics and pharmacodynamics of ADCs involve multiple mechanisms, including internalization of ADCs by target cells, intracellular trafficking, release of conjugated drugs, and payload.
Conclusion:
These mechanisms actually jointly determine the efficacy of ADCs. Therefore, the optimization of ADCs should take them as necessary rationales.
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