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Related Concept Videos

Spermatogenesis01:41

Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
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During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
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Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
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During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
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Related Experiment Video

Updated: Apr 8, 2026

Mouse Round Spermatid Injection
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Does sperm origin affect embryo morphokinetic parameters?

Jenna Lammers1,2,3, Arnaud Reignier1,2,4,3, Carole Splingart1,2,3

  • 1Service de Médecine et Biologie de la Reproduction, CHU de Nantes, Nantes, 44093, France.

Journal of Assisted Reproduction and Genetics
|June 26, 2015
PubMed
Summary
This summary is machine-generated.

Sperm origin (fresh ejaculate vs. surgically retrieved) did not significantly impact intracytoplasmic sperm injection (ICSI) cycle outcomes. While some early embryo morphokinetics differed, late events showed delays in surgically retrieved sperm groups, but clinical relevance remains unclear.

Keywords:
AzoospermiaICSIMorphokineticSurgically retrieved spermTime-lapse

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Area of Science:

  • Reproductive Science
  • Embryology
  • In Vitro Fertilization

Background:

  • Sperm origin can influence assisted reproductive technology outcomes.
  • Understanding the impact of fresh ejaculated versus surgically retrieved sperm is crucial for optimizing intracytoplasmic sperm injection (ICSI) protocols.

Purpose of the Study:

  • To evaluate the effect of sperm origin (fresh ejaculate vs. surgically retrieved) on embryo morphokinetics and clinical outcomes in ICSI cycles.
  • To compare early and late morphokinetic parameters between fresh ejaculated and surgically retrieved sperm groups.

Main Methods:

  • Retrospective monocentric study of 604 ICSI cycles using Embryoscope® time-lapse imaging.
  • Comparison of embryo morphokinetics and clinical outcomes between fresh ejaculated sperm (n=445) and surgically retrieved sperm (n=40) groups.
  • Subgroup analysis of testicular versus epididymal sperm.

Main Results:

  • Clinical outcomes were comparable between fresh ejaculated and surgically retrieved sperm groups.
  • Most early embryo morphokinetic parameters showed no significant differences, despite some variations with overlapping distributions.
  • Late cellular events occurred significantly later in the surgically retrieved sperm group compared to the fresh ejaculated sperm group.

Conclusions:

  • Morphokinetic analysis did not reveal clinically significant differences between fresh ejaculate and surgically retrieved sperm groups.
  • Further research is needed to clarify the relationship between sperm origin and late morphokinetic parameters, particularly blastocyst development.