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Cardiomyocyte-Driven Actuation in Biohybrid Microcylinders.

Jaewon Yoon¹, Tom W Eyster², Asish C Misra³

¹Macromolecular Science and Engineering Program, University of Michigan, Ann Arbor, MI, 48109, USA.

Advanced Materials (Deerfield Beach, Fla.)

|June 26, 2015

Summary

Researchers created biohybrid microcylinders with enhanced cell adhesion for bioactuators. These microcylinders respond to rat cardiomyocyte contractions, showing potential for micromechanical systems.

Keywords:

bioactuators biodegradable polymers electrohydrodynamic cojetting microparticles surface chemistry

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Area of Science:

Biomaterials Engineering
Cellular Mechanics
Microsystems Engineering

Background:

Biohybrid actuators require precise cell alignment and tunable mechanical properties.
Current fabrication methods may not adequately control cell-matrix interactions for optimal performance.

Purpose of the Study:

To fabricate biohybrid microcylinders with maximized cell-adhesive properties.
To characterize the spatial cell selectivity and mechanical stress/strain response of these microcylinders.
To evaluate their potential for use in bioactuators responding to cardiomyocyte contraction.

Main Methods:

Fabrication of biohybrid microcylinders via electrohydrodynamic cojetting.
Surface chemistry modification to enhance cell adhesion.
Characterization of spatial cell distribution and mechanical properties (stress/strain).
Assessment of response to rat cardiomyocyte contraction.

Main Results:

Successfully fabricated biohybrid microcylinders with improved cell-adhesive characteristics.
Demonstrated control over spatial cell selectivity within the microcylinders.
Characterized the stress/strain properties, indicating responsiveness to cellular forces.
Validated the microcylinders' capability to respond to rat cardiomyocyte contraction.

Conclusions:

Electrohydrodynamic cojetting and surface chemistry enable fabrication of advanced biohybrid microcylinders.
These microcylinders exhibit promising properties for bioactuator design, including controlled cell alignment and mechanical responsiveness.
The developed microcylinders hold potential for applications in various micromechanical systems and bioactuators.